A prospective observational study of urinary cytokines and inflammatory response in patients with Overactive Bladder Syndrome

Abstract Background Contemporary studies have discredited the methods used to exclude urinary tract infection (UTI) when treating overactive bladder (OAB). Thus we must revisit OAB phenotype check that UTI has not been overlooked. Aims To examine differences in cytokines IL6 and lactoferrin patients compared controls, with references microscopy of urine enhanced quantitative culture. Methods A blinded, prospective cohort study normal controls using six repeated measures, achieved two-monthly, over 12 months. Results The between (F = 49.0, p < .001) 228.5, were significant a magnitude clinical implications. These for correlated symptoms (9.3, .003); both pyuria (IL6 F 66.2, .001, Lactoferrin 73.9, .001); microbial abundance 5.1, .024). pathological markers had missed by dipsticks routine MSU Conclusion may encompass is being overlooked because failure standard screening methods.